School of Medicine Publications and Presentations

Association between Helicobacter Pylori infection and stroke: a meta-analysis of 273,135 patients

Document Type

Article

Publication Date

9-2021

Abstract

Background

Stroke stands among the most leading causes of mortality worldwide. Although modifiable risk factors for stroke have been identified, current risk factors do not sufficiently explain the risk in young patients. Previous studies have postulated an association between infection by Helicobacter pylori (HP) and stroke.

Objective

To investigate the association between HP infection and stroke by using a systematic review and meta-analysis approach.

Methods

Four electronic search engines/libraries were systematically searched for relevant observational studies. Studies were screened for eligibility and data were extracted. The odds ratio (OR) and 95% confidence interval (95% CI) were combined under the random-effect model. The protocol was registered in PROSPERO (CRD42019123689).

Results

Among the included studies, 25 studies were analyzed for anti-HP IgG, 9 studies were for anti-Cag A, and 6 studies were for the C-urea breath test. The results showed that positive anti-HP IgG was significantly associated with an increased risk of stroke [OR (95% CI) = 1.43 (1.25–1.46)]. Similarly, both antiCag A and C-urea breath test were significantly associated with an increased risk of stroke with [OR (95% CI) = 1.77 (1.25–2.49)], and [OR (95% CI) = 2.21 (1.33–3.66)], respectively. Furthermore, our results indicated that positive anti-HP IgG was associated with stroke caused by atherothrombosis and small artery disease.

Conclusions

This study suggests that HP infection is significantly associated with increased risk of stroke. However, more well-designed studies are required to investigate if early HP eradication might decrease the incidence of stroke.

Comments

Copyright © 2020, Springer-Verlag GmbH Germany, part of Springer Nature

https://rdcu.be/c2Idi

Publication Title

J Neurol

DOI

10.1007/s00415-020-09933-x

Academic Level

faculty

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