Talks
Cross-linked nanocomplexes for drug delivery applications
Presentation Type
Oral Presentation
Discipline Track
Clinical Science
Abstract Type
Research/Clinical
Abstract
Background: Nanotechnology often overcomes the chemotherapy associated issues. Nanotechnology- based carriers primarily aimed to improve the therapeutic efficacy of anticancer agents by increasing bioavailability, solubility, and retention time at the tumor sites. On the other hand, nanoparticle technology offers the improved tumor targeting capability of therapeutic drug(s), which in turn reduces the systemic side effects. Such events reduce dosing frequency in a chemotherapy regimen. Among various types of nanocarriers, naturally occurring compound based nanocomplexes have been receiving extensive attention in drug delivery applications. Therefore, the goal of this study was to investigate the potential utility of modified pectin and tannic acid cross-linked nanocomplexes (MPT-NCs) for cancer therapeutic application.
Methods: We developed and used an innovative approach of highly stable nanocomplexes based on modified pectin and tannic acid (MPT-NCs). The nanoassemblies formation was enabled by strong intermolecular interactions between pectin and tannic acid under very mild conditions. These nanoassemblies were characterized by particle size and morphology (DLS, TEM, and SEM), FT-IR spectroscopy, and zeta potential measurements. Its delivery capacity has been determined for anticancer drugs using pancreatic cancer cell-line models.
Results: Spherical formation of nanoselfassemblies were determined by DLS, SEM, and TEM analysis. The composition is identified by FT-IR spectra. Cellular uptake studies demonstrated a time and dose dependent internalization for improved therapeutic benefit. Cell viability and clonogenic formation assays clearly validated the superior anticancer effects against pancreatic cancer cells.
Conclusions: Altogether, this study findings suggest that nanocomplexes based strategy can be an efficient drug delivery approaches.
Academic/Professional Position
Undergraduate
Mentor/PI Department
Immunology and Microbiology
Recommended Citation
Chauhan, Sumeet S.; Shetty, Advait B.; Hatami, Elham; Chowdhury, Pallabita; and Yallapu, Murali M., "Cross-linked nanocomplexes for drug delivery applications" (2023). Research Symposium. 51.
https://scholarworks.utrgv.edu/somrs/theme1/track1/51
Cross-linked nanocomplexes for drug delivery applications
Background: Nanotechnology often overcomes the chemotherapy associated issues. Nanotechnology- based carriers primarily aimed to improve the therapeutic efficacy of anticancer agents by increasing bioavailability, solubility, and retention time at the tumor sites. On the other hand, nanoparticle technology offers the improved tumor targeting capability of therapeutic drug(s), which in turn reduces the systemic side effects. Such events reduce dosing frequency in a chemotherapy regimen. Among various types of nanocarriers, naturally occurring compound based nanocomplexes have been receiving extensive attention in drug delivery applications. Therefore, the goal of this study was to investigate the potential utility of modified pectin and tannic acid cross-linked nanocomplexes (MPT-NCs) for cancer therapeutic application.
Methods: We developed and used an innovative approach of highly stable nanocomplexes based on modified pectin and tannic acid (MPT-NCs). The nanoassemblies formation was enabled by strong intermolecular interactions between pectin and tannic acid under very mild conditions. These nanoassemblies were characterized by particle size and morphology (DLS, TEM, and SEM), FT-IR spectroscopy, and zeta potential measurements. Its delivery capacity has been determined for anticancer drugs using pancreatic cancer cell-line models.
Results: Spherical formation of nanoselfassemblies were determined by DLS, SEM, and TEM analysis. The composition is identified by FT-IR spectra. Cellular uptake studies demonstrated a time and dose dependent internalization for improved therapeutic benefit. Cell viability and clonogenic formation assays clearly validated the superior anticancer effects against pancreatic cancer cells.
Conclusions: Altogether, this study findings suggest that nanocomplexes based strategy can be an efficient drug delivery approaches.