School of Podiatric Medicine - Medical Student Research
Document Type
Poster
Publication Date
Fall 7-25-2024
Abstract
Water regulation in the central nervous system (CNS) is very crucial to maintain normal neurophysiological homeostasis, intracranial pressure and play a role in the pathogenesis of edema and brain disorders. Not only because of the rigidity and limited mobility of the brain encasement that offer little room for fluid expansion, but also the need to maintain an appropriate osmotic balance across the various fluid-filled brain compartments which is necessary for normal neurological functions. Aquaporins (AQPs), a family of non-energy dependent, bidirectional water transport protein channels, play a critical role in maintaining water and electrolyte balance in human brain. The distribution and expression of AQPs in different regions of the brain need to be characterized to definitively certify and associate their pathogenic role in neuropathological disorders. In this study, we investigated the expression and location of AQP water transport channels in human brain using histology and immunohistochemistry. The data characterized the expression and anatomical locations of AQP water transport channels in various regions of human brain, corresponding to the physiological functions of the three major AQP (AQP1, AQP4, and AQP9) water transport protein channels found in adult human brain.
Recommended Citation
Mudasiru, Oyinkansola; Etugbo, Vivian; and Adiele, Reginald, "A Systematic Study of the Distribution and Expression of Aquaporin Water Channels in Normal Adult Human Brain" (2024). School of Podiatric Medicine - Medical Student Research. 15.
https://scholarworks.utrgv.edu/sopm_mspub/15
