School of Podiatric Medicine - Student Research

Document Type

Poster

Publication Date

2024

Abstract

Introduction: AM grafts are angiogenic, anti-inflammatory, anti-fibrotic, anti-microbial, non-immunogenic, and decrease the total time for complex, chronic wounds to heal. This poster will explore a single case study using an AM graft on an elderly male with a chronic wound and provide a brief overview of the general application of AM in chronic wounds.

Case Report: A healthy 92-year-old male sustained a traumatic wound to the dorsum of his foot after dropping a heavy welding torch. The wound was chronically neglected and progressed to tendons before he was taken in for evaluation and treatment. Through a series of amniotic graft applications, the patient was able to fully heal within 4 months post-presentation.

Methods: “Amniotic tissue” AND “lower extremity” AND “chronic wound” were searched in PubMed and Google Scholar. Fifteen papers were found. When non-relevant, non-English, or diabetes-only articles were removed, there were four articles were reviewed.

Results: 4 articles represented 73 patients with complex, chronic, non-healing wounds of various etiologies with time to heal ranging from 3 to 22 weeks. One article did not report the length of time to heal.

Discussion: Our investigation suggests that the use of amniotic grafts greatly reduces the time to complete wound healing, lowers rates of graft rejection compared to other skin grafts, and an effective treatment for patients with large, complex non-healing wounds of various etiologies.

Conclusion: Application of AM reduces pain, scarring, wound complication, and recovery duration of chronic wounds and aided our patient in complete healing in four months.

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