Theses and Dissertations

Date of Award

8-1-2024

Document Type

Thesis

Degree Name

Master of Science (MS)

Department

Biochemistry and Molecular Biology

First Advisor

Ezzat El-Sherif

Second Advisor

Yonghong Zhang

Third Advisor

Robert Gilkerson

Abstract

Although Insects and vertebrates have different anatomical structures, they possess similar mechanisms for segmenting during embryogenesis. Clock and wavefront model exhibit a similar pattern of division as observed in Drosophila, like vertebrates, which emphasizes fundamental principles in the field of developmental biology. In contrast to Drosophila, the insect Tribolium castaneum exhibits posterior segmentation originating from the growth zone. The pair-rule genes’ expression is characterized by oscillatory patterns, which are controlled by a segmentation clock. Researchers found that the speed regulation model combines oscillatory and sequential gene activities to shape both elongating and non-elongating embryonic tissues. The adaptability of this model is responsible for the evolutionary shift from short-germ to long-germ segmentation. The model demonstrates hierarchical gene activation and periodic expressions of pair-rule genes in Tribolium and the segmentation clock mechanism. The extensive research on segmentation processes among different species highlights the significance of principles in developmental biology.

Comments

Copyright 2024 Hasan Mahmud. https://proquest.com/docview/3115250832

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