Microwave-Assisted Green Synthesis of Spiroindolinopyranopyrazoles

Author

Esther Owusu, The University of Texas Rio Grande Valley

Date of Award

12-1-2024

Document Type

Thesis

Degree Name

Master of Science (MS)

Department

Chemistry

First Advisor

Debasish Bandyopadhyay

Second Advisor

Narayan Bhat

Third Advisor

Mohammed Uddin

Abstract

Green Chemistry, usually known as sustainable chemistry, is widely implemented worldwide to safeguard human health and the environment. Recent investigations in organic synthesis and chemical transformation have demonstrated that green chemistry techniques are significantly reducing both chemical waste and reaction time. In order to fulfill this ecological requirement, it is crucial to lessen the utilization of perilous solvents and noxious chemicals, while also creating innovative reaction methods that decrease the production of trash. The implementation of such methodologies can greatly enhance the field of green chemistry. A more environmentally friendly synthetic method was utilized to generate spiro chemicals and their derivatives through a five-component reaction. The synthesis involved the use of 1,3-Diketo, hydroxyl amine, activated methylene, isatin, and nitrogen source. The experiment employed microwave irradiation for a specific duration ranging from 5 to 15 minutes, while maintaining a moderate temperature of 80°C. The solvent used was water, with N, N-Diisopropylethylamine (DIPEA) acting as the catalyst, leading to a significant production of products.

Comments

Copyright 2024 Esther Owusu. https://proquest.com/docview/3153338552

Recommended Citation

Owusu, Esther, "Microwave-Assisted Green Synthesis of Spiroindolinopyranopyrazoles" (2024). Theses and Dissertations. 1635.
https://scholarworks.utrgv.edu/etd/1635