Genetic Determinants of Variation in the GH/IGF-1 Axis and Their Relationship to Cardiometabolic Health

Author

Rafael Luis Aguirre Guillen, The University of Texas Rio Grande Valley

Date of Award

12-2019

Document Type

Thesis

Degree Name

Master of Science (MS)

Department

Biology

First Advisor

Dr. John Blangero

Second Advisor

Dr. Robert K Dearth

Third Advisor

Dr. Megan Keniry

Abstract

Background: In a study of Mexican Americans, we performed analyses of GEI and pleiotropy in the axis in relation to MS. GH/IGF-1 axis components were studied. Model parameters and likelihoods were estimated by maximum likelihood.

Results: Pleiotropy was observed for IGFBP3 (p

Conclusions: IGF-I and IGFBP3 are genetically correlated with MS whereas MS influences the additive genetic variance in IGFBP1 variables mainly but also in IGF-I somewhat by virtue of the VH exhibited by IGF-I/IGFBP1.

Comments

Copyright 2019 Rafael Luis Aguirre Guillen. All Rights Reserved.

https://go.openathens.net/redirector/utrgv.edu?url=https://www.proquest.com/dissertations-theses/genetic-determinants-variation-gh-igf-1-axis/docview/2382571786/se-2?accountid=7119

Recommended Citation

Aguirre Guillen, Rafael Luis, "Genetic Determinants of Variation in the GH/IGF-1 Axis and Their Relationship to Cardiometabolic Health" (2019). Theses and Dissertations. 422.
https://scholarworks.utrgv.edu/etd/422