Date of Award
Master of Science (MS)
Dr. John Blangero
Dr. Robert K Dearth
Dr. Megan Keniry
Background: In a study of Mexican Americans, we performed analyses of GEI and pleiotropy in the axis in relation to MS. GH/IGF-1 axis components were studied. Model parameters and likelihoods were estimated by maximum likelihood.
Results: Pleiotropy was observed for IGFBP3 (p
Conclusions: IGF-I and IGFBP3 are genetically correlated with MS whereas MS influences the additive genetic variance in IGFBP1 variables mainly but also in IGF-I somewhat by virtue of the VH exhibited by IGF-I/IGFBP1.
Aguirre Guillen, Rafael Luis, "Genetic Determinants of Variation in the GH/IGF-1 Axis and Their Relationship to Cardiometabolic Health" (2019). Theses and Dissertations - UTRGV. 422.