Theses and Dissertations
Date of Award
5-2023
Document Type
Thesis
Degree Name
Master of Science (MS)
Department
Biochemistry and Molecular Biology
First Advisor
Dr. Upal Roy
Second Advisor
Dr. Mario Gil
Third Advisor
Dr. Hansapani Rodrigo
Abstract
According to the world health organization (WHO), 37.7 million people worldwide in 2020 were living with the human immunodeficiency virus (HIV-1). In the US, combination antiretroviral therapy (cART) drugs have shown effectiveness in combating HIV-1 infection. As a result, cART has prolonged the lifespan of people with HIV aiding these patients to age with the virus. Clinical evidence has established the long-term effects of cART in the aging population causing neuropsychiatric disorders such as depression. However, the underline molecular mechanism that cART induces depression-related neurodegeneration has not been established. This study will pursue a dopamine (DA) dysregulation marker in cART treatment through in vitro conditions. Additionally, this study will establish the role of human protein DJ-1 as a neuronal marker and its correlation with other neuronal proteins. Characterizing the correlation between DJ-1 and cART mediated neurodegeneration will contribute to the early detection of depression.
Recommended Citation
Bustos, Andrea S., "Dopamine Dysregulation in Antiretroviral Drugs Treated Neuronal Cells" (2023). Theses and Dissertations. 1198.
https://scholarworks.utrgv.edu/etd/1198
Comments
Copyright 2023 Andrea S. Bustos. All Rights Reserved.
https://go.openathens.net/redirector/utrgv.edu?url=https://www.proquest.com/dissertations-theses/dopamine-dysregulation-antiretroviral-drugs/docview/2842768854/se-2?accountid=7119