Date of Award
Master of Science (MS)
Biochemistry and Molecular Biology
Dr. Upal Roy
Dr. Mario Gil
Dr. Hansapani Rodrigo
According to the world health organization (WHO), 37.7 million people worldwide in 2020 were living with the human immunodeficiency virus (HIV-1). In the US, combination antiretroviral therapy (cART) drugs have shown effectiveness in combating HIV-1 infection. As a result, cART has prolonged the lifespan of people with HIV aiding these patients to age with the virus. Clinical evidence has established the long-term effects of cART in the aging population causing neuropsychiatric disorders such as depression. However, the underline molecular mechanism that cART induces depression-related neurodegeneration has not been established. This study will pursue a dopamine (DA) dysregulation marker in cART treatment through in vitro conditions. Additionally, this study will establish the role of human protein DJ-1 as a neuronal marker and its correlation with other neuronal proteins. Characterizing the correlation between DJ-1 and cART mediated neurodegeneration will contribute to the early detection of depression.
Bustos, Andrea S., "Dopamine Dysregulation in Antiretroviral Drugs Treated Neuronal Cells" (2023). Theses and Dissertations. 1198.
Available for download on Friday, July 25, 2025